Myotonic dystrophy type 1 (DM1) is the most common form of adult-onset muscular dystrophy, affecting about 1 in 8,000 people. While it is well known for causing muscle weakness and stiffness, DM1 also affects other organs, including the brain, heart and gastrointestinal (GI) tract. Although around 80% of people with DM1 experience GI problems that greatly reduce their quality of life, including difficulty swallowing, delayed stomach emptying, constipation and severe conditions like intestinal obstruction, the underlying causes remain understudied.
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