Nine consultant surgeons from The Christie hospital in Manchester will swap their scrubs for running vests as they take part in a team, organised by urological surgeon Aziz Gulamhusein.
They are aiming to raise funds for The Christie Charity, which support patients and their families.
In the elite race Jack Rowe, who broke the course record last year finishing in 1:02:40, is back to defend his title.
People are being encouraged to cheer their friends and family at two new cheer zones – one at Deansgate Interchange and the second the “Buzz Hub’” at Wharfside.
More than 100 roads are to be closed for the event – click here for a full list. , external
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