Police said these residents were being supported by Cheshire East Council, with Crewe Lifestyle Centre being used as a rest centre for those affected.
There are no reports of any injuries and a number of road closures remain in place while the work continues at the scene.
Supt Claire Jesson said: “I’d like thank residents for their patience while emergency services continue to work tirelessly at the scene.
“We understand people will want to get back into their properties as soon as they can, and we are all working hard to ensure that it is safe for you to do so.
“Agencies will continue to work with displaced residents to keep them updated as to when they can return.
“While our colleagues from Cheshire Fire and Rescue Service tackle the fire, we continue to urge residents in the nearby area to stay indoors with their windows and doors closed at this time.”
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