The Dragon launch had been scheduled for Thursday but was delayed because of Hurricane Helene, which has left a trail of destruction through Florida, north through Georgia and into Tennessee and the Carolinas.
SpaceX, founded by billionaire Elon Musk, has been ferrying crews to and from the ISS every six months.
The Dragon is expected to dock with the ISS on Sunday at around 21:30 GMT.
Under a contract between Nasa and Roscosmos, the Russian federal space agency, three-seat Russian Soyuz spacecraft carry one Nasa astronaut on each flight to the ISS and a cosmonaut flies on each four-seat Dragon.
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