Wales, who have been beaten in all four games in this campaign, are bidding to avoid a 17th successive Test defeat and 11th Six Nations loss on the bounce.
Wales’ most recent Test match victory came against World Cup pool opponents Georgia in October 2023.
They have also lost their previous eight home games in Cardiff and been defeated in the past eight Six Nations matches at the Principality Stadium.
Wales are also bidding to avoid a clean sweep of defeats in successive tournaments for the first time in their history.
Warren Gatland departed as head coach in February following a dismal 22-15 defeat by Italy in February, with Sherratt in charge for the final three games of the tournament.
In contrast, England will arrive at the Principality Stadium as title contenders, although a France bonus-point victory against Scotland later on Saturday night will guarantee Les Bleus top spot.
“Wales England is always a special occasion and we know it will be an incredible atmosphere at Principality Stadium,” said Sherratt.
“We’re excited to finish our campaign at home and are looking to put in our best performance on the pitch on Saturday.”
BBC News
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