A healthy bone marrow (BM) produces nearly all types of cells in our blood. Many blood disorders occur when hematopoietic stem cells (HSCs) in the BM malfunction. Treatment with radiation or chemotherapy for many blood disorders and cancers can, as a side effect, deplete not only tumor cells but also hematopoietic cells, including HSCs in the BM—a condition known as myelosuppression. In severe cases, HSC transplantation (HSCT) is required to restore hematopoiesis.
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