Muscular dystrophy is a genetic disorder which usually affects young males, resulting in progressive muscle degeneration.
Mr Hywood lost his ability to walk in 2020 and has become a full-time wheelchair user.
He was hired by Muscular Dystrophy UK in 2021 and helps to raise thousands of pounds for the charity.
“I feel like I have the best job in the world,” he said, adding that he hoped to raise £300,000 from the night of comedy.
Other comedians including Kojo Amin, Matt Forde, Suzi Ruffell and Tim Vine are also due to perform.
Talking to the BBC ahead of the show, Mr Hywood said: “I am extremely nervous, I feel responsible for the event.”
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