[
A lower-protein diet could be associated with better control of uremic toxins in patients starting peritoneal dialysis (PD) at a lower dose (incremental PD), according to a study published online Aug. 6 in Nutrients.
Silvio Borrelli, M.D., Ph.D., from the University of Campania “Luigi Vanvitelli” in Naples, Italy, and colleagues conducted an interim analysis of the I-COPE PD study cohort that aimed to assess one-year changes in serum albumin, body mass index (BMI) and metabolic parameters in 205 patients on incremental PD. Patients were categorized into two groups according to protein diet prescription: protein diet (PrD) ≤0.6 g/kg/day (45.4% of patients) and PrD >0.6 g/kg/day. Longitudinal changes were analyzed at baseline and at six and 12 months.
The researchers found that the prevalence of patients persisting in incremental PD did not differ between the two dietary groups (59.1% versus 63.3% in PrD ≤0.6 versus PrD >0.6). A similar trend in serum albumin was seen in both groups, characterized by an initial decline followed by stabilization. No significant differences were observed in BMI. Compared with the PrD >0.6 group, patients on PrD ≤0.6 exhibited significantly lower serum urea, phosphate and potassium levels over time, despite comparable dialysis adequacy.
“Our observational analysis provides, for the first time, suggestive data on the benefits and safety of reducing protein in the diets of patients starting PD with an incremental approach,” the authors write.
Two authors disclosed ties to biopharmaceutical companies, including Vantive, which partially funded the study.
Publication details
Silvio Borrelli et al, One-Year Nutritional and Metabolic Changes in Patients on Incremental Peritoneal Dialysis Under Different Protein Diets: A Multicenter Pragmatic Cohort Study, Nutrients (2026). DOI: 10.3390/nu18152565
Journal information:
Nutrients
Clinical categories
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Lower protein diet may be better in incremental peritoneal dialysis (2026, August 18)
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