Glasgow Warriors forwards Jack Dempsey, Max Williamson and Gregor Brown have all dropped out of the Scotland squad as Gregor Townsend’s side prepare to face Portugal on Saturday.
Clubmate Johnny Matthews and Scarlets prop Alex Hepburn have been called up as replacements.
Number eight Dempsey picked up a shoulder injury after starting Sunday’s defeat by South Africa.
Lock Williamson suffered a hand injury after coming on as an early replacement following Scott Cummings’ red card, while flanker Brown, who did not feature at Murrayfield, has a rib injury.
Hooker Matthews, who has one Scotland cap, was a surprise absentee from Townsend’s original squad following fine try-scoring form for his club.
Fellow 31-year-old Hepburn has four caps.
Portugal visit Murrayfield on Saturday in the second of Scotland’s Autumn Series internationals, which conclude with the visit of Australia on 24 November.
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