Firefighters are using four water bowsers, two aerial ladder platforms, and a high volume pump (HVP) to tackle the flames.
A cordon covering Frogmore Street, Regent Street, Princes Street and Baker Street is expected to remain in place for some time.
Police urged residents to ensure all windows and doors were closed due to the smoke.
Richard John, a Conservative councillor for Mitchel Troy and Trellech ward, described the fire as “horrendous” and “heartbreaking” as he thanked emergency services on X, external, formerly known as Twitter.
Laura Wright, a Labour councillor for Grofield ward, said the fire was “absolutely devastating”.
She spoke of her gratitude, external to those “working hard to get everything under control and make sure that residents are safe”.
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