The long-term stasis of blood in the liver, known as chronic liver congestion, can lead to a range of diseases, some of which are fatal. However, identifying how liver congestion causes these diseases has remained unclear, causing difficulty in proposing the best treatment pathway. In a study published in Gastroenterology, Japanese researchers have identified a molecular pathway connecting liver congestion to liver fibrosis, portal hypertension, and liver tumorigenesis. This finding has important implications for potential therapies.
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