Widespread disruption to businesses, rail services, and GP practices has been sparked by a global IT outage.
Great Western Railway said its trains are running as normal, but passengers have been experiencing difficulties with ticket issuing and on-screen customer information.
In Bristol and Somerset, patients are being turned away from GP and medical practices as clinical systems are down.
A number of shops are now cash-only, and Bristol Airport has urged passengers to check with airlines before travelling.
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