Rail services on Transport for Wales, Transpennine Express and Northern Rail face significant disruption.
Greater Manchester Police (GMP) said a person had been arrested on suspicion of drink driving following the crash.
A force spokesperson said: “Please expect some delays this morning while remedial works are carried out.”
Network Rail said the line was expected to be closed “for the majority of the day”.
It said: “We’re really sorry to any passengers affected by this incident and urge anyone planning to travel by train between Liverpool and Manchester to plan ahead and check with their train operator for the latest travel information.”
BBC News
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