Eight fire engines from Lancashire Fire and Rescue Service’s fleet were called to the incident.
Fire crews have urged people to avoid the area while they deal with the incident, which was likely to take “some hours”.
Lancashire Police said the injured man had managed to get out of the property by the time officers had arrived.
A joint investigation is set to be launched to “establish the cause and circumstances that led to the suspected gas explosion” while efforts are under way to make the house safe, it added.
Anyone with information about the incident has been asked to contact police.
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