Drivers are facing delays of nearly two hours after four lorries and a tanker crashed on the northbound carriageway of the M6.
Three lanes of the motorway were closed after the crash between junctions 18 and junctions 19 in Knutsford, Cheshire, just after 04:00 BST.
Cheshire Police said “one person is believed to have sustained serious injuries”.
He has been taken to the Royal Stoke Hospital but his injuries are not believed to be life threatening.
National Highways said there were 12 miles of queues and a “large spillage” on the motorway.
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