Key points on the Beverley to Hull route are due to include North Ferriby village hall (09:35), Haltemprice leisure centre (10:35), Costello Stadium (11:35) and Queen Victoria Square (12:35).
He is due to arrive at Craven Park, the home of Hull KR, at about 13:40.
It is Mr Sinfield’s fourth consecutive annual event for MND charities, having already raised almost £10m in previous fundraisers.
He began the challenge on Sunday in Liverpool, where he took part in an annual Santa Dash.
On Friday, he will run between Northampton and Leicester, before the finale on Saturday between Old Trafford and Saddleworth.
Listen to highlights from Hull and East Yorkshire on BBC Sounds, watch the latest episode of Look North or tell us about a story you think we should be covering here, external.
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