In an earlier statement, Laurel County Sheriff’s Office said that “numerous persons” had been shot.
A spokesperson for the University of Kentucky Medical Center in Lexington told the BBC’s US news partner, CBS News that it had received at least two patients from the incident so far, but there was no word on their conditions.
Trooper Scottie Pennington, a Kentucky State Police spokesperson, urged residents in the area to stay inside.
Members of the public have been warned not to approach the person of interest.
The Bureau of Alcohol, Tobacco, Firearms, and Explosives also confirmed it was involved in the search.
Earlier, Kentucky’s Governor Andy Beshear wrote on social media that law enforcement had “shut the interstate down in both directions” near to where the shooting happened.
He said the area should be avoided, and urged the public to “pray for everyone involved”.
London is a small city of about 8,000 residents near the Daniel Boone National Forest.
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