The first fire began on Tuesday in the Pacific Palisades neighbourhood, near Malibu, with others subsequently breaking out across the north of the city.
As of 20:15 local time (04:00 GMT), four fires in the areas of the Palisades, Pasadena, Sylmar, and the Hollywood Hills covered more than 27,000 acres (42 sq miles; 109 sq km) and were 0% contained, according to the LAFD.
One fire in the Acton area had been partially contained, while two others had been completely contained.
The fire in the Hollywood Hills – a residential neighbourhood overlooking the historic Hollywood area of the city – began at around 18:00 local time on Wednesday.
Less than two hours later, much of the heart of Hollywood was blanketed with thick smoke, and the tops of the palm trees that line its streets were barely visible.
People used sweatshirts to cover their faces to help them breathe, while others – clearly surprised by the fire – wore only pyjamas. Many carried bags and suitcases, talking on their phones as they made plans for where to go.
Many of the roads near the fire – including Hollywood Boulevard, home to the Hollywood Walk of Fame – were gridlocked with traffic. Some people even drove on the wrong side of the road as they tried to get out of the area.
Resident Anna Waldman told the BBC she had set out to walk her dog but smelled smoke almost instantly when she went outside.
She went back inside and, looking out her back windows, saw fire, and watched as it moved quickly thought the Hollywood Hills, coming to within a block of her home.
She packed what she could: food, clothes, blankets, food for her three small dogs.
“I can’t believe this,” she said in exhaustion, pulling down her face mask.
Makayla Jackson, 26, and her two-year-old son, Ramari, had been evacuated from a homeless shelter that was in danger of burning, and now stood on the street waiting for a ride to a high school where help was being offered to people.
“They just told us to get out and go,” she said.
BBC News