Avanti West Coast told passengers: “Please do not attempt to travel with us between Preston and Scotland.
“We’re really sorry if this affects your journey today.”
The company told ticketholders they can travel with other operators such as LNER on the East Coast Main Line, postpone their journey or request a refund.
TransPennine Express commercial director Darren Higgins said: “Due to flooding on the railway line north of Carlisle, train services are significantly disrupted.
“The safety of our customers and colleagues is our priority and we are urging customers not to travel between Manchester, Liverpool (or) Preston to Carlisle, Glasgow and Edinburgh.
“Anyone planning on travelling by train today can choose to defer their travel or claim a refund.”
ScotRail services between Carlisle and Glasgow Central are expected to start or terminate at Dumfries.
A yellow weather warning for rain is still in place for the majority of Scotland until 18:00 and for northern England and the Midlands until 12:00.
The Met Office warned there is a slight risk of power cuts and a small chance that some homes and businesses could be flooded.
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