Det Ch Insp Lorett Spierenburg, who is leading the investigation, said: “This is an incredibly difficult time for Michael Wheeler’s family, who understandably are incredibly worried and desperate to know what has happened to him.”
She added police had been “keeping an open mind” over what had happened to Mr Wheeler, but inquires had now turned to a murder investigation.
She also confirmed arrests had been carried out last week “to enable us to question several individuals while under caution to understand if they knew anything that could help us locate Michael”.
Four of those individuals have now been re-arrested on suspicion of murder in the past 24-hours, along with a fifth man who was not arrested last week, she said.
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