A research team led by Associate Professor Shinpei Yamaguchi and the late Professor Masako Tada of the Faculty of Science, together with Professor Yojiro Anzai and Lecturer Yohei Iizaka of the Faculty of Pharmaceutical Sciences at Toho University, have developed a new HepaRG cell line with markedly enhanced activity of CYP2D6, a major drug-metabolizing enzyme. This engineered human hepatocyte model enables more human-relevant evaluation of drug-induced hepatotoxicity mediated by CYP2D6. The study was published in the journal PLOS ONE on December 29, 2025.
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