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Circular single-stranded DNA molecules for safer genetic medicine

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To our immune system, a potentially lifesaving gene therapy can look a lot like a dangerous infection. That’s because most genetic medicine uses viruses or double-stranded DNA to deliver genetic information to target cells. DNA in its traditional double helix form can lead to toxic immune stimulation and be difficult to package into cellular delivery vehicles. As a result, the reach of genetic medicine is limited today.


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