The gene most strongly correlated with Alzheimer’s disease also boosts seizure activity by decreasing levels of ion pumps and energy-producing enzymes in neurons, a new study by researchers at the University of Illinois Urbana-Champaign has found. Furthermore, the energy-making pathway was stimulated and seizures reduced in mouse models of Alzheimer’s disease by administration of a blood pressure medication, pointing to a potential treatment to reduce seizure activity in those with the gene, APOE4.
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