As well as its brewery and distillery, Adnams runs 11 pubs and hotels and has a further 34 partner pubs across Suffolk, Norfolk, Cambridgeshire and Essex.
The company announced operating losses of £2.5m in 2023, blaming higher costs.
Current non-executive director Simon Townsend will become chairman on an interim basis.
He said: “The Adnams family, business and community owes a debt of gratitude to Jonathan for the contribution he’s made over a 50-year career.
“His personal commitment to innovation – in our products, through to our brewing and distilling capabilities – has been instrumental in building the foundations we continue to benefit from today.”
He added he was “committed to securing the long-term financial solution we need to support our growth”.
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