

Christina Applegate is opening up about living with multiple sclerosis, the unpredictable and potentially debilitating disease she was diagnosed with in 2021.
“I live kind of in hell. I’m not out a lot, so this is a little difficult, just for my system. But of course, the support is wonderful, and I’m really grateful,” Applegate said in an interview with “Good Morning America.”
Applegate received a standing ovation at the Emmys in January when she appeared on stage with a cane as a surprise presenter. She cracked a joke about her condition saying, “You’re totally shaming me with disability by standing up, but it’s fine.”
The actor admitted she “kind of blacked out” in that moment.
“People said, ‘Oh, you were so funny,’ and I’m like, I don’t even know what I said. I don’t know what I was doing. I got so freaked out that I didn’t even know what was happening anymore,” Applegate said in the interview.
“I felt really beloved, and it was a beautiful thing,” she added.
Jamie-Lynn Sigler accompanied Applegate in the interview. Sigler herself was diagnosed with multiple sclerosis when she was 20 years old. The two are now hosting the new podcast, “MeSsy.”
Applegate first shared her diagnosis in 2021 through social media. The actor has since given fans updates about her health.
Multiple sclerosis is a disease of the central nervous system that disrupts the flow of information between the brain and body, according to the National Multiple Sclerosis Society. The immune system attacks the body’s nerve linings, producing unpredictable symptoms including pain, fatigue or even paralysis.
Khamrah by Lattafa for Men - 3.4 oz EDP Spray
4% OffGhost Sweetheart Eau de Toilette | Pineapple, Jasmine and Sandalwood | Perfume for Women 50 ml
50% OffMarc Jacobs Dot Eau De Parfum for Women, 100 ml
42% OffTed Baker W Eau de Toilette for Her, Fig Leaf, White Peony and Violet Top Notes, Pink Orchid and Raspberry Middle Notes, 75ml
£11.77 (£15.69 / 100 ml) (as of 23/06/2026 03:34 GMT +01:00 - More infoProduct prices and availability are accurate as of the date/time indicated and are subject to change. Any price and availability information displayed on [relevant Amazon Site(s), as applicable] at the time of purchase will apply to the purchase of this product.)Ted Baker Woman Pink Eau de Toilette Spray Floral Green Feminine Fragrance, Opening Notes are Fresh Peach, Bergamot and Tangerine with Warm Musk, Vanilla and Vetiver Base, 100ml
11% OffVera Wang Princess Eau de Toilette - 30 ml
Choco Musk 50ml Eau De Parfum for men and women | Chocolate Musk by Jannat Aromas
17% OffChristina Aguilera Signature Eau de Parfum (50ml) Floral, Fruity & Exotic Scent, Luxury Fragrance for Women
9% OffCalvin Klein - Eau De Toilette CKIN2U - Calvin Klein Women, Ladies Perfume, Women's Perfume, Calvin Klein Perfume, Calvin Klein One - 150 ml
5% OffJimmy Choo Flash Eau de Parfum, 60 ml (Pack of 1)
3% OffFruit of the Loom Men's Heavy T Shirt, White, XL UK
28% OffATNKE LED Lighted Beanie Cap,USB Rechargeable Running Hat Ultra Bright 4 LED Waterproof Light Winter Warm Gifts for Men and Women/Pink
Now retrieving the rating.
17% OffMen's 1/4 Zip Pullover UK Sale Clearance, Fleece Sweatshirt Casual Jumper Long Sleeve T-shirt Top Stand Collar Sweater Plain Pullover Sports Leisure Workwear Quarter Zip Sweater Lightweight Jumpers
Now retrieving the rating.
£5.88 (as of 12/11/2025 00:52 GMT +01:00 - More infoProduct prices and availability are accurate as of the date/time indicated and are subject to change. Any price and availability information displayed on [relevant Amazon Site(s), as applicable] at the time of purchase will apply to the purchase of this product.)