Mr Irranca-Davies, the climate change and rural affairs aecretary, stood on a “joint unity ticket” with Ms Morgan for the Welsh Labour leadership.
The health portfolio can be seen as something of a poisoned chalice, given the huge challenges facing the NHS and social services.
But the last three first ministers had all previously done the health job.
Whoever takes on the post might not be there long.
It is possible the appointment will be temporary, ahead of a full cabinet reshuffle next month.
The new first minister was nominated by Senedd members, recalled from their summer break to replace Vaughan Gething, who resigned last month.
He quit after four members of his cabinet resigned their jobs, and Ms Morgan was elected unopposed as Welsh Labour leader.
Mr Gething, Wales’ first black first minister, became mired in controversy after accepting donations from a man twice convicted of environmental offences for his election campaign and sacking one of his cabinet ministers over leaked messages.
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