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Tag Archives: Reductions

Non-covalent btki pirtobrutinib shows promise as frontline therapy for CLL/SLL

[ Credit: Unsplash/CC0 Public Domain Pirtobrutinib, a non-covalent Bruton tyrosine kinase (BTK) inhibitor, met the primary endpoint for non-inferiority in terms of overall response rate in the first head-to-head comparison with ibrutinib, a covalent BTK inhibitor. Based on the study results, researchers suggest pirtobrutinib shows promise as initial BTK inhibitor …

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Declines in driving frequency, complexity seen for drivers with mild cognitive impairment

[ Drivers with mild cognitive impairment (MCI) have declines in driving frequency, complexity, and spatial range, according to a study published online Nov. 26 in Neurology. Ling Chen, Ph.D., from the Brown School of Social Work in St. Louis, and colleagues conducted a prospective, observational cohort study of community-dwelling older …

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Construction activity shrank ‘at fastest pace since COVID’ ahead of budget | Money News

The UK’s construction sector suffered its sharpest contraction in activity since May 2020, according to a closely-watched survey taken before this month’s budget. S&P Global’s monthly purchasing managers’ index (PMI) covering November makes grim reading for the government. The survey of business behaviour showed steep falls in all three sub-sectors …

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Clinical use of nitrous oxide could help treat depression, major study shows

[ Credit: Unsplash/CC0 Public Domain Patients with major depressive disorder, including those who have not responded to first-line antidepressants, may benefit from short-term nitrous oxide treatment, a major meta-analysis led by the University of Birmingham has found. The paper published in eBioMedicine has assessed the best available clinical information to …

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Negative consequences do not deter young adults from using alcohol and cannabis together, study finds

[ Credit: Unsplash/CC0 Public Domain Young adults who experience negative consequences from using both alcohol and cannabis simultaneously are likely to have fewer drinks the next time they drink, but are more likely to use cannabis and alcohol together. This unexpected finding from a study just published in Alcohol: Clinical …

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Schizophrenia-spectrum disorders may originate in specific brain regions that show early structural damage

[ Researchers at the University of Seville have identified the possible origins of structural damage in the brains of patients with schizophrenia spectrum disorders (SSDs). These are regions that show the greatest morphological alterations in the early stages of the disease compared to neurotypical people of the same sex and …

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HER2-targeted therapy shows promising results in rare bile duct cancers

[ Credit: Pixabay/CC0 Public Domain Zanidatamab, a bispecific HER2-targeted antibody, delivered clinically meaningful and durable responses for patients with HER2-positive biliary tract cancer (BTC), according to final results from the HERIZON-BTC-01 clinical trial led by researchers at The University of Texas MD Anderson Cancer Center. In this clinical trial, zanidatamab …

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