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Tag Archives: Placebo

Metformin shown to prevent long COVID across risk groups in multiple randomized trials

[ Credit: CC0 Public Domain Multiple randomized clinical trials and electronic health record studies now show that metformin, a widely used and well-established medication, significantly reduces the risk of developing long COVID when taken during or shortly after acute infection with SARS-CoV-2. The findings are published in Clinical Infectious Diseases. …

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Machine learning can predict patients' responses to antidepressants—while disentangling drug and placebo effects

[ Depression is one of the most widespread mental health disorders worldwide, affecting approximately 4% of the global population. It is characterized by a persistent low mood, disruptions in typical sleeping and/or eating habits, a lack of motivation, a loss of interest in daily activities and unhelpful thought patterns. Source …

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Experimental antibody enables lasting platelet stability in autoimmune bleeding condition

[ Credit: Pixabay/CC0 Public Domain More than half of patients in a Phase III clinical trial who received a limited course of the experimental monoclonal antibody ianalumab for primary immune thrombocytopenia (ITP), an autoimmune disorder that can cause life-threatening bleeding, were able to maintain safe platelet counts without serious bleeding …

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Fecal microbiota transplant may help patients with IBS and depressive symptoms

[ Credit: Andrea Piacquadio from Pexels A meta-analysis of randomized trials suggests fecal microbiota transplantation can ease depressive symptoms, with stronger effects reported for endoscopic or enema delivery, according to researchers at the Department of Nursing, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine. …

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BMS-986504 demonstrates durable responses in MTAP-deleted NSCLC, including EGFR and ALK-positive tumors

[ Credit: CC0 Public Domain BMS-986504, a first-in-class methylthioadenosine (MTA)-cooperative protein arginine methyltransferase 5 (PRMT5) targeting agent, showed promising antitumor activity in heavily pretreated patients with MTAP-deleted non-small cell lung cancer (NSCLC), according to results from the Phase I CA240-0007 trial presented at the International Association for the Study of …

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Nivolumab maintains quality of life and reduces symptom deterioration in resectable NSCLC, trial shows

[ Credit: Pixabay/CC0 Public Domain An analysis from the Phase III CheckMate 77T trial confirms that perioperative nivolumab does not compromise health-related quality of life (HRQoL) in patients with resectable non-small cell lung cancer (NSCLC), including those with Stage III N2 disease. These results were presented at the International Association …

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Osimertinib plus chemotherapy improves progression-free survival in EGFR-mutated non-small cell lung cancer

[ Credit: Pixabay/CC0 Public Domain A new analysis from the COMPEL trial shows that patients with EGFR-mutated (EGFRm) advanced non-small cell lung cancer (NSCLC) who experienced non-central nervous system (CNS) progression on first-line osimertinib benefit from continuing osimertinib treatment in combination with platinum-based chemotherapy. The study was presented at the …

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