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Ulster captain Iain Henderson has been left out of Ireland’s 37-strong squad for the Six Nations.
The second row, 33, made his Ireland debut in 2012 and has won 85 caps, including five Six Nations titles and two Grand Slams.
Leinster prop Andrew Porter will miss the start of the Six Nations with a calf injury while Robbie Henshaw, Calvin Nash, Jimmy O’Brien.
Ulster forward Cormac Izuchukwu is also unavailable for selection.
Munster back row Edwin Edogbo and Ulster scrum-half Nathan Doak are the two uncapped players in Andy Farrell’s squad.
Hugo Keenan has been named despite not featuring for Leinster or Ireland since the British and Irish Lions tour of Australia last summer.
Ireland open their Six Nations campaign against holders France in Paris on Thursday, 5 February.
Farrell’s side then host Italy and visit England before two final matches in Dublin with Wales and Scotland.
Ireland won the Triple Crown in 2025 but finished third in the table behind France and England.
Wing Mack Hansen is a notable omission as he is set to miss the remainder of the season with a foot injury.
Henderson, 33, returned on New Years Day from a back injury that had kept him out since November.
Despite a number of injuries over the years he has been a regular for Ireland both under Joe Schmidt and Farrell, and is a two-time British and Irish Lion in 2017 and 2021.
There is no place for former Ireland Rugby Sevens stars Zac Ward and JJ Kenny, who have impressed on the wing for Ulster and Leinster respectively but have not been selected by Farrell.
BBC News
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