Two other passengers in the VW, a 16-year-old girl and a 17-year-old boy, suffered serious injuries.
The girl remains in a critical condition and the boy is in a serious condition, police said.
A passenger in the Vauxhall, a man aged 62, was taken to hospital with serious injuries along with the driver, a 34-year-old woman who sustained a serious arm injury.
Two other passengers in that car suffered minor injuries.
The arrested teenager has been released on bail while inquiries continue.
Police have renewed an appeal for witnesses and dashcam footage of the crash.
Listen to highlights from Hull and East Yorkshire on BBC Sounds, watch the latest episode of Look North or tell us about a story you think we should be covering here, external.
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