Tandy, who names his side on Wednesday morning, will ask his players to back up their encouraging performance against the Scots as they bid to cause an upset and end a 14-game losing run in the Six Nations.
Mee started against England and France in the first two rounds but missed out against the Scots, when Hamer-Webb made his Test debut.
The Leicester wing showed flashes but was also centre stage for the try by Darcy Graham that was created by Finn Russell’s sharp thinking from a quick restart.
The Scotland and Lions fly-half exploited the space left by former Cardiff back Hamer-Webb after he had chased Jarrod Evans’ successful penalty kick.
Blair Murray came on for Hamer-Webb when he suffered an early nose injury and then was a permanent replacement for the final quarter but it is Mee, who is strong in the aerial game, who is poised to get the nod for Dublin.
Botham came on in the first half of the game against Scotland and was a strong performer, although he was also caught out by Russell’s restart.
The combative flanker will join forces with Cardiff team-mate Alex Mann, with number eight Wainwright an injury concern.
Edwards, who had started seven matches before being dropped against Scotland, will pull the strings after Costelow’s bright display was ended by an ankle injury.
Harlequins’ Evans has been used off the bench five times by Tandy and has not started a Test match since 2021.
Wales have not beaten Ireland away in the Six Nations since 2012 or achieved a victory in Dublin since 2015.
The Irish suffered an opening round defeat by France in Paris but have since beaten Italy and England to keep alive their title hopes, while they can also win the Triple Crown.
BBC News
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