Wales injury doubts Kieffer Moore and Chris Mepham have travelled to Dublin ahead of Sunday’s Nations League match against the Republic of Ireland.
Cardiff City striker Moore was forced off during the 3-0 friendly loss to England at Wembley with a bruised toe.
Bournemouth defender Mepham picked up a knee injury late on and both players will be assessed.
Juventus midfielder Aaron Ramsey has linked up with the squad in Dublin after missing the England game.
Ramsey was part of the club’s Covid-19 bubble following an outbreak.
Wales are light on forward options to replace Moore, with Hal Robson-Kanu already out of the squad after breaking his arm.
“We’re going to assess it,” said Wales manager Ryan Giggs, speaking after the England defeat on Thursday night.
“We’re not too sure if Moore will be fit for Sunday.
“I thought he was a handful, a real threat. The game changed with the [first England] goal but when Kieffer went off, we lost that target.
“And also on set-pieces, where we conceded two bad goals, he’s a big part of that, defending set-pieces.”
Moore would be sorely missed if he was to be ruled out of Wales’ trip to Dublin on Sunday.
The physically imposing Cardiff City striker has established himself as an important first-team player under Giggs, scoring three goals in his eight appearances to date and helping Wales qualify for next summer’s European Championship.
After their match against the Republic of Ireland, Wales visit Bulgaria on Wednesday.
Although Robson-Kanu’s withdrawal leaves Moore as the only out-and-out centre-forward, Giggs does not anticipate he will call up a replacement even if the Cardiff striker is unavailable through injury.
That is because Wales are in their own “bubble”, an enclosed environment to comply with coronavirus protocols, and any additional call-ups would require testing before they can join the squad for training.
“No, it will be very difficult because we’re in the bubble,” Giggs said when asked if Wales might call for cover.
“We’ve been tested today [Thursday] so I don’t think it would be possible.
“We have got other options but hopefully he will be OK and it is only bruised.”